Quantum Composers Attenuators in New Spectroscopy Study

28 July 2016, Posted in Applications

B-16-LIBS

Quantum Composers has a rich history of working with engineers and scientists in academia around the world, synchronizing hardware for demanding and complex experiments. Our Pulse Generator and Laser instruments are used in a wide variety of applications and functions. A few typical examples are PIV, LIDAR and LIBS. This article highlights the use of our laser attenuators for a Laser Induced Breakdown Spectroscopy application involving nanoparticles in living tissues. This exciting research was presented by our customer, the Institue Lumiere in France and the team was utilizing our ATT1064 computer controlled attenuator.

3D Imaging of Nanoparticle Distribution in Biological Tissue by Laser-Induced Breakdown Spectroscopy

Abstract
Nanomaterials represent a rapidly expanding area of research with huge potential for future medical applications. Nanotechnology indeed promises to revolutionize diagnostics, drug delivery, gene therapy, and many other areas of research. For any biological investigation involving nanomaterials, it is crucial to study the behavior of such nano-objects within tissues to evaluate both their efficacy and their toxicity. Here, we provide the first account of 3D label-free nanoparticle imaging at the entire-organ scale. The technology used is known as laser-induced breakdown spectroscopy (LIBS) and possesses several advantages such as speed of operation, ease of use and full compatibility with optical microscopy. We then used two different but complementary approaches to achieve 3D elemental imaging with LIBS: a volume reconstruction of a sliced organ and in-depth analysis. This proof-of-concept study demonstrates the quantitative imaging of both endogenous and exogenous elements within entire organs and paves the way for innumerable applications.

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